United States securities and exchange commission logo





                          August 20, 2020

       Maurice Zauderer
       President and Chief Executive Officer
       VACCINEX, INC.
       1895 Mount Hope Avenue
       Rochester, New York 14620

                                                        Re: VACCINEX, INC.
                                                            Registration
Statement on Form S-3
                                                            Filed August 14,
2020
                                                            File No. 333-246322

       Dear Dr. Zauderer:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Margaret
Schwartz at 202-551-7153 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences