Form 424B4
VACCINEX, INC. filed this Form 424B4 on 08/10/2018
Document Outline
Entire Document (3881.5 KB)
Subdocument 1 - 424B4 - 424B4
Page 1 - Filed Pursuant to Rule 424(b)(4)
Page 2 - TABLE OF CONTENTS
Page 3 - PROSPECTUS SUMMARY
Page 4 - Vaccinex Product Pipeline
Page 5 - Other Product Candidates
Page 6 - VX25
Page 7 - Emerging Growth Company
Page 8 - The Offering
Page 9 - N/A
Page 10 - Summary Consolidated Financial Data
Page 11 - N/A
Page 12 - N/A
Page 13 - RISK FACTORS
Page 14 - We will require additional capital to finance our operations, which may not be available to us on ac
Page 15 - Our ability to continue as a going concern will require us to obtain additional financing to fund ou
Page 16 - Risks Related to Our Business and Industry
Page 17 - If we experience delays in clinical testing, we will be delayed in obtaining approval of our product
Page 18 - We may not successfully identify, develop or commercialize potential product candidates.
Page 19 - We may be required to suspend, repeat or terminate our clinical trials if they are not conducted in
Page 20 - We are subject to multiple manufacturing risks, any of which could substantially increase our costs
Page 21 - Even if our product candidates receive regulatory approval, they may still face future development a
Page 22 - One of the indications we are pursuing for our lead product candidate VX15 is for the treatment of H
Page 23 - Our failure to obtain regulatory approval in international jurisdictions would prevent us from marke
Page 24 - Our competitors may develop and market products or services that are less expensive, more effective,
Page 25 - We may not be able to achieve the benefits or synergistic effects of VX15 in combination with other
Page 26 - We do not currently have any sales, marketing or distribution experience or infrastructure and may r
Page 27 - Current and future legislation may increase the difficulty and cost for commercialization of our pro
Page 28 - If we are able to successfully commercialize any of our product candidates and if we participate in
Page 29 - Our relationships with customers and third-party payors will be subject to applicable anti-kickback,
Page 30 - Our employees may engage in misconduct or other improper activities, including noncompliance with re
Page 31 - We depend on key personnel for our continued operations and future success and a loss of certain key
Page 32 - We depend on third-party manufacturers for the manufacture of drug substance and drug product for cl
Page 33 - Collaborations may require us to relinquish important rights to and control over the development of
Page 34 - N/A
Page 35 - We may not be able to protect our intellectual property rights throughout the world.
Page 36 - Changes in patent law and legal precedent concerning patents could diminish the value of patents in
Page 37 - We may become involved in lawsuits to protect or enforce our intellectual property rights, which cou
Page 38 - Third parties may initiate legal proceedings against us alleging that we infringe their intellectual
Page 39 - Our inability to protect our confidential information and trade secrets would harm our business and
Page 40 - We have broad discretion in the use of the net proceeds from this offering and may not use them effe
Page 41 - If securities or industry analysts do not publish research or publish inaccurate or unfavorable rese
Page 42 - We will incur significant increased costs as a result of operating as a public company, and our mana
Page 43 - Our disclosure controls and procedures may not prevent or detect all errors or acts of fraud.
Page 44 - N/A
Page 45 - SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
Page 46 - IMPLICATIONS OF BEING AN EMERGING GROWTH COMPANY
Page 47 - USE OF PROCEEDS
Page 48 - DIVIDEND POLICY
Page 49 - CAPITALIZATION
Page 50 - N/A
Page 51 - DILUTION
Page 52 - N/A
Page 53 - SELECTED CONSOLIDATED FINANCIAL DATA
Page 54 - N/A
Page 55 - MANAGEMENT S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
Page 56 - Financial Overview
Page 57 - General and Administrative. Our general and administrative expenses consist primarily of compensatio
Page 58 - Interest Expense
Page 59 - Operating Expenses
Page 60 - Comparison of the Years Ended December 31, 2016 and 2017
Page 61 - Interest Expense
Page 62 - Cash Flows
Page 63 - Investing Activities. Cash used in investing activities during the years ended December 31, 2016 and
Page 64 - Convertible Promissory Notes
Page 65 - Contractual Obligations
Page 66 - Foreign Currency Risk
Page 67 - Stock-Based Compensation
Page 68 - Common Stock Valuations
Page 69 - Income Taxes and Net Operating Loss Carryforwards
Page 70 - Derivative Liabilities
Page 71 - Recent Accounting Pronouncements Not Yet Adopted
Page 72 - BUSINESS
Page 73 - Vaccinex Product Pipeline
Page 74 - Huntington s Disease
Page 75 - N/A
Page 76 - Background on the Immune System and Antibodies
Page 77 - Our SEMA4D Antibody Platform
Page 78 - Collaboration and IST Agreements
Page 79 - Emory
Page 80 - Figure 1. SEMA4D Expression Concentrated at Tumor Growing Edge
Page 81 - Figure 3. Anti-SEMA4D Antibody Increases Cytotoxic T Cells in Tumor
Page 82 - Figure 5. SEMA4D Gradient at Invasive Tumor Margin Regulates Migration and
Page 83 - Figure 6. Anti-SEMA4D Treatment Shifts the Balance of Cytokines and Chemokines in the Tumor Microenv
Page 84 - Figure 7A. Combination Treatment with Anti-CTLA-4 and Anti-SEMA4D in a Colorectal Tumor
Page 85 - Current Approaches to Cancer Treatment
Page 86 - Our Approach to a Combination Therapy in Cancer
Page 87 - Figure 8. Treatment of PLXNB1 and ErbB-2 Double Positive Mammary Carcinoma with Anti-SEMA4D Delays T
Page 88 - Completed Phase 1 Clinical Trials
Page 89 - Ongoing and Planned Phase 1b/2 Clinical Trials
Page 90 - VX15 in Huntington s Disease
Page 91 - Figure 10. VX15 Promotes Migration of Oligodendrocyte Precursor Cells
Page 92 - Current Approaches to the Treatment of Huntington s Disease
Page 93 - Our Approach to Huntington s Disease
Page 94 - Figure 12. VX15 Treatment Significantly Inhibits Cortical and Corpus Callosum Degeneration in Brains
Page 95 - Figure 13. VX15 May Improve Spatial Memory in the YAC128 Mouse Model
Page 96 - Figure 14. MRI: Mean Change from Baseline in Regions of Frontal and Parietal Cortex
Page 97 - Figure 15. FDG-PET: Mean Change from Baseline in Regions of Frontal and Parietal Cortex
Page 98 - Our Approach to Antibody Discovery
Page 99 - Discovery Collaborations with Third Parties
Page 100 - Catalent Pharma Solutions
Page 101 - BVX20 for Multiple Sclerosis
Page 102 - Intellectual Property
Page 103 - SEMA4D Antibody Platform and VX15
Page 104 - ActivMAb Antibody Discovery Platform
Page 105 - ActivMAb Platform Patents. Three patent families covering the ActivMAb platform are wholly owned by
Page 106 - Patent Protection
Page 107 - Trade Secret Protection
Page 108 - Preclinical Testing. Before testing any compound in human subjects, a sponsor must develop extensive
Page 109 - The BLA Process
Page 110 - N/A
Page 111 - Postmarketing Commitments. The FDA may require, or companies may pursue, additional clinical trials
Page 112 - Advertising and Promotion. The FDA and other federal and state agencies regulate the labeling, marke
Page 113 - N/A
Page 114 - Federal and State Fraud and Abuse and Data Privacy and Security Laws and Regulations
Page 115 - Healthcare Reform
Page 116 - N/A
Page 117 - Regulation Outside of the United States
Page 118 - N/A
Page 119 - VX3
Page 120 - N/A
Page 121 - MANAGEMENT
Page 122 - Alan L. Crane has served as a member of our board of directors since March 2003. Since February 2002
Page 123 - Bala S. Manian, Ph.D. has served as a member of our board of directors since December 2004. Dr. Mani
Page 124 - Raymond E. Watkins has served as our Senior Vice President and Chief Operating Officer since January
Page 125 - Independence of the Board of Directors and Board Committees
Page 126 - Role of the Board in Risk Oversight
Page 127 - Audit Committee
Page 128 - Code of Business Conduct and Ethics
Page 129 - EXECUTIVE AND DIRECTOR COMPENSATION
Page 130 - Other Benefits
Page 131 - Stock Options. The 2018 Plan will authorize our compensation committee to grant incentive stock opti
Page 132 - Performance Awards. The 2018 Plan will permit the grant of performance-based stock and cash awards.
Page 133 - Amendment; Termination. Our compensation committee may amend or terminate the 2018 Plan at any time;
Page 134 - Share Reserve. As of June 30, 2018, stock options to purchase a total of 22,500 shares of our common
Page 135 - Director Compensation
Page 136 - Limitation of Liability and Indemnification Agreements
Page 137 - N/A
Page 138 - CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS
Page 139 - Series D Redeemable Convertible Preferred Stock Financing
Page 140 - Participation in this Offering
Page 141 - N/A
Page 142 - PRINCIPAL STOCKHOLDERS
Page 143 - N/A
Page 144 - N/A
Page 145 - DESCRIPTION OF CAPITAL STOCK
Page 146 - Fully Paid and Nonassessable
Page 147 - Incidental Registration Rights
Page 148 - Section 203 of the Delaware General Corporation Law
Page 149 - Transfer Agent and Registrar
Page 150 - SHARES ELIGIBLE FOR FUTURE SALE
Page 151 - Rule 701
Page 152 - MATERIAL U.S. FEDERAL INCOME AND ESTATE TAX CONSEQUENCES TO NON-U.S. HOLDERS
Page 153 - Distributions
Page 154 - Information Reporting Requirements and Backup Withholding
Page 155 - N/A
Page 156 - UNDERWRITING
Page 157 - N/A
Page 158 - Electronic Delivery of Preliminary Prospectus
Page 159 - N/A
Page 160 - France
Page 161 - Sweden
Page 162 - N/A
Page 163 - LEGAL MATTERS
Page 164 - VACCINEX, INC.
Page 165 - REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
Page 166 - VACCINEX, INC.
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Page 202 - 3,333,334 Shares