United States securities and exchange commission logo





                          April 3, 2024

       Maurice Zauderer, Ph.D.
       President and Chief Executive Officer
       Vaccinex, Inc.
       1895 Mount Hope Avenue
       Rochester, NY 14620

                                                        Re: Vaccinex, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed April 2, 2024
                                                            File No. 333-278467

       Dear Maurice Zauderer:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jason
Drory at 202-551-8342 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Nick Hoover