United States securities and exchange commission logo August 20, 2020 Maurice Zauderer President and Chief Executive Officer VACCINEX, INC. 1895 Mount Hope Avenue Rochester, New York 14620 Re: VACCINEX, INC. Registration Statement on Form S-3 Filed August 14, 2020 File No. 333-246322 Dear Dr. Zauderer: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Margaret Schwartz at 202-551-7153 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences