SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Frieberg Jacob B. (Last) (First) (Middle) C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE (Street) ROCHESTER NY 14620 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol VACCINEX, INC. [ VCNX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 05/11/2021
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock								52,866	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Option (Right to Acquire)(1)	(1)							(1)	(1)	Common Stock	4,420		44,200	D
Option (Right to Acquire)(1)	(1)							(1)	(1)	Common Stock	4,420		44,200	I	By Benbow Estates, Ltd.(2)
Option (Right to Acquire)(3)	(3)							(3)	(3)	Common Stock	4,121		75,000	I	By Gee Eff Services Limited(4)
Stock Option (Right to Buy)	$13.6							(5)	09/15/2027	Common Stock	6,396		6,396	D
Stock Option (Right to Buy)	$5.26							(5)	03/30/2029	Common Stock	2,501		2,501	D
Stock Option (Right to Buy)	$7.78							(5)	(6)	Common Stock	7,718		7,718	D
Stock Option (Right to Buy)	$5.52							(5)	06/29/2029	Common Stock	2,385		2,385	D
Stock Option (Right to Buy)	$7.17							(5)	09/27/2029	Common Stock	1,856		1,856	D
Stock Option (Right to Buy)	$4.85							(5)	12/28/2029	Common Stock	2,737		2,737	D
Stock Option (Right to Buy)	$4							(5)	03/29/2030	Common Stock	3,336		3,336	D
Stock Option (Right to Buy)	$3.95							05/14/2021	(7)	Common Stock	15,679		15,679	D
Stock Option (Right to Buy)	$3.61							(5)	06/28/2030	Common Stock	3,756		3,756	D
Stock Option (Right to Buy)	$1.78							(5)	09/28/2030	Common Stock	7,626		7,626	D
Stock Option (Right to Buy)	$2.07							(5)	12/29/2030	Common Stock	6,545		6,545	D
Stock Option (Right to Buy)	$2.98							(5)	03/31/2031	Common Stock	4,535		4,535	D
Stock Option (Right to Buy)	$2.15	05/11/2021		A		28,586		05/11/2022	(8)	Common Stock	28,586	$0	28,586	D

Explanation of Responses:

1. Limited partnership units of Vaccinex Products, LP, which are presently exchangeable into shares of Common Stock on a 1-for-10 basis at the holder's option.

2. Mr. Frieberg's spouse is the owner of Benbow Estates, Ltd. and Mr. Frieberg is an officer of Benbow Estates, Ltd. Mr. Frieberg disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

3. Partnership interests in VX3 (DE) LP, or VX3, which are presently exchangeable into shares of Common Stock on a 1-for-0.05495 basis at the holder's option. On August 13, 2018, Gee Eff Services Limited entered into an exchange agreement with the Issuer and the other partners of VX3 that provides each VX3 partner the right to exchange all, but not less than all, of its partnership interests in VX3 for shares of Common Stock. The option has no expiration date.

4. Mr. Frieberg is the sole owner and President of Gee Eff Services Limited.

5. Exercisable in full as of the date of this report.

6. This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first.

7. This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first.

8. This option was granted pursuant to the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and expires on May 9, 2031 or five years following retirement or cessation of services, whichever occurs first.

Remarks:

	/s/ Scott E. Royer, Attorney-in-Fact for Jacob B. Frieberg	05/12/2021
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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